It’s possible by S7-PLCSIM V5.4 incl. SP3

Multiple startability and communication support between the CPUs

But it has the following limitations.

1.Multicomputing is not supported by S7-PLCSIM: S7-PLCSIM cannot simulate SIMATIC stations with several CPUs (multicomputing).

2.Point-to-point communication (such as between two S7-400 CPUs in the same rack) is not supported.

The connection via the MPI interface is the default setting for the simulated PLC in S7-PLCSIM.Subsequently the simulated PLC will start with the last used connection class.

These Can be simulated:

A file *.PLC is used to save the simulated PLC. The following information is saved:

● Program

● Hardware configuration

● Operating mode

● current status of the I/O